ISSN 1662-4009 (online)

ey0019.15-8 | Assorted Conditions | ESPEYB19

15.8. Serum testosterone levels in 3-month-old boys predict their semen quality as young adults

Henriksen L Scheutz , Petersen J Holm , NE Skakkebaek , N Jorgensen , HE Virtanen , L Priskorn , A Juul , J Toppari , KM Main

J Clin Endocrinol Metab. 2022;107(7):1965-75. doi: 10.1210/clinem/dgac173.PubMed ID: 35323957Brief summary: This population-based birth cohort study related infancy serum testosterone concentrations at age 3 months to parameters of reproductive function at age 18 to 20 years in 259 males. Serum testosterone in infancy predicted adult total sperm counts, and other reproductive hormones and geni...

ey0015.8-5 | New Mechanisms | ESPEYB15

8.5 Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla

A Furlan , V Dyachuk , ME Kastriti , L Calvo-Enrique , H Abdo , S Hadjab , T Chontorotzea , N Akkuratova , D Usoskin , D Kamenev , J Petersen , K Sunadome , F Memic , U Marklund , K Fried , P Topilko , F Lallemend , PV Kharchenko , P Ernfors , I Adameyko

To read the full abstract: Science. 2017; 357(6346)Current textbooks teach that adrenergic chromaffin cells of the adrenal medulla originate from a sympathoadrenal cell lineage of the neural crest nearby the dorsal aorta. Here, Furlan et al. demonstrate a novel origin of these neuroendocrine cells of the medulla arising predominantly from Schwamm cell precursors (SCP) of peripheral nerves. Prev...

ey0016.5-14 | Basic Science - Growth Plate | ESPEYB16

5.14. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

PT Newton , L Li , B Zhou , C Schweingruber , M Hovorakova , M Xie , X Sun , L Sandhow , AV Artemov , E Ivashkin , S Suter , V Dyachuk , M El Shahawy , A Gritli-Linde , T Bouderlique , J Petersen , A Mollbrink , J Lundeberg , G Enikolopov , H Qian , K Fried , M Kasper , E Hedlund , I Adameyko , L Savendahl , AS Chagin

Abstract: Nature. 2019 Mar;567(7747):234–238.In brief: In this article, the authors present evidence that the murine epiphyseal growth plate develops a postnatal stem cell niche with monoclonal properties, that are able to self-renew. They thereby challenge the concept of a continous depletion of progenitor cells as a limiting factor for bone growth.<p class="abste...